
Madrid's press called him El Muro, and he earned it across 337 matches for the club, having already done the rare thing of playing a World Cup for Uruguay in 1954 and another for Spain in 1962. He won four European Cups with Real Madrid in 1958, 1959, 1960 and 1966, six Spanish league titles, the 1960 Intercontinental Cup and a Copa del Generalísimo. Career record: 20 caps and 0 goals for Uruguay; club career at Club Nacional de Football, Real Madrid Club de Fútbol.
| 1948–1957 | Club Nacional de Football |
| 1957–1966 | Real Madrid Club de Fútbol |
| Uruguay | 20 caps, 0 goals |
Uruguay legends whose careers overlapped Santamaría's
One rank above: José Nasazzi at #6.
One rank below: Obdulio Varela at #8.
Uruguay's editorial top five: Juan Alberto Schiaffino · Luis Suárez · Enzo Francescoli · Héctor Scarone · José Leandro Andrade.