
Porto led 1-0 in Rome on 23 August 2016 when he rounded Wojciech Szczęsny and rolled the ball into an empty net, the second in a 3-0 win that put Roma out of the Champions League play-off. He won Mexico's 2015 Gold Cup and CONCACAF Cup, appeared at two World Cups, took the Primeira Liga with Porto in 2018, three Liga MX titles with América and one with Monterrey, and the CONCACAF Champions League in 2019 and 2021. Career record: 71 caps and 6 goals for Mexico; club career at Tiburones Rojos de Veracruz, Club América, Club de Fútbol Monterrey.
| 2006–2006 | Querétaro |
| 2007–2009 | Tiburones Rojos de Veracruz |
| 2009–2010 | Atalanta BC |
| 2010–2014 | Club América |
| 2014–2015 | Watford |
| 2015–2018 | FC Porto |
| 2018–2018 | Sevilla |
| 2018–2019 | Villarreal CF |
| 2019–2021 | Club de Fútbol Monterrey |
| 2021–2023 | Club América |
| Mexico | 71 caps, 6 goals |
Mexico legends whose careers overlapped Layún's
One rank above: Ignacio Flores at #29.
One rank below: Fernando Quirarte at #31.
Mexico's editorial top five: Hugo Sánchez · Rafael Márquez · Andrés Guardado · Cuauhtémoc Blanco · Guillermo Ochoa.